| Primary Identifier | IPR005629 | Type | Family |
| Short Name | Skn1/Kre6/Sbg1 |
| description | This family consists of the beta-glucan synthesis-associated proteins SKN1, KRE6 and Sbg1. Beta1,6-Glucan is a key component of the yeast cell wall, interconnecting cell wall proteins, beta1,3-glucan, and chitin. SKN1 and KRE6 show similarities to glycoside hydrolase family 16 glycoside hydrolases, suggesting that they are glycosyl hydrolases or transglycosylases []. Loss of KRE6 shows reduced levels of both beta-1,3-glucan and beta-1,6-glucan synthesis, while loss of SKN1 affects sphingolipid biosynthesis [], being related with the synthesis and anchorage of cell wall proteins of glucan polymers of the yeast cell wall, although they play redundant roles []. SKN1, KRE6 and Sbg1 share the SKN1 domain, which is conserved in SKN1 and KRE6 proteins of many fungal species. Sbg1 is an integral membrane protein essential for contractile-ring constriction and septum formation during cytokinesis, which interacts with the conserved beta-glucan synthase Bgs1 and regulates its protein levels and localisation [, ]. |
