| First Author | Zhu X | Year | 1994 |
| Journal | J Biol Chem | Volume | 269 |
| Issue | 8 | Pages | 5518-22 |
| PubMed ID | 8119884 | Mgi Jnum | J:16951 |
| Mgi Id | MGI:65008 | Doi | 10.1016/s0021-9258(17)37491-4 |
| Citation | Zhu X, et al. (1994) Interleukin-2-induced tyrosine phosphorylation of Shc proteins correlates with factor-dependent T cell proliferation. J Biol Chem 269(8):5518-22 |
| abstractText | Interleukin-2 (IL-2) is a growth factor involved in the clonal expansion of antigen-activated T lymphocytes. Interaction of IL-2 with its receptor triggers tyrosine phosphorylation of a series of proteins and results in the activation of p21ras. We report here that Shc, an SH2-containing adaptor protein, is tyrosine-phosphorylated following IL-2 stimulation. IL-2-induced tyrosine phosphorylation of Shc was detectable within seconds following IL-2 addition, reaching its highest level by 15 min. Tyrosine phosphorylation of Shc was induced in multiple IL-2-dependent T cell lines and was found to correlate with IL-2-dependent cell proliferation. Tyrosine-phosphorylated Shc was found to be capable of associating with the SH2 domain of Grb2 following IL-2 stimulation. These results indicate that tyrosine phosphorylation of Shc and its association with Grb2 may be important events in IL-2-initiated signal transduction events in T cells. |
