| First Author | Tanaka Y | Year | 1999 |
| Journal | J Biol Chem | Volume | 274 |
| Issue | 40 | Pages | 28067-70 |
| PubMed ID | 10497154 | Mgi Jnum | J:57999 |
| Mgi Id | MGI:1346286 | Doi | 10.1074/jbc.274.40.28067 |
| Citation | Tanaka Y, et al. (1999) B-myb is required for inner cell mass formation at an early stage of development. J Biol Chem 274(40):28067-70 |
| abstractText | The myb gene family has three members, c-myb, A-myb, and B-myb, which have distinct expression patterns. Analyses of c-myb and A-myb mutant mice have indicated that c-myb and A-myb are important for hematopoiesis and spermatogenesis, respectively. However, there has been no evidence for a role for B-myb in development. To examine the role of B-myb in development, we generated B-myb-deficient mice by gene targeting. Although the heterozygous mutants were healthy, the homozygous mutants died at an early stage of development, around E4. 5-E6.5. In vitro culture of blastocyst indicated that B-myb is required for inner cell mass formation. Consistent with the important role of B-myb in early embryonic development, only B-myb among myb family members was expressed in embryonic stem cells. These results indicate that each of the three members of the myb gene family plays a distinct role during development. |
