| First Author | Gascoigne NR | Year | 1984 |
| Journal | Nature | Volume | 310 |
| Issue | 5976 | Pages | 387-91 |
| PubMed ID | 6336329 | Mgi Jnum | J:7518 |
| Mgi Id | MGI:55988 | Doi | 10.1038/310387a0 |
| Citation | Gascoigne NR, et al. (1984) Genomic organization and sequence of T-cell receptor beta-chain constant- and joining-region genes. Nature 310(5976):387-91 |
| abstractText | The genomic structure of the joining (J) and constant (C) regions of the locus encoding the beta-chain of the murine T-cell receptor has been analysed. The gene segments are arranged tandemly (J-C/J-C) within a 15-kilobase region. The two constant-region genes are almost identical, differing by only four amino acids, all in carboxy-terminal portions. Each C region comprises four exons encoding an external globular domain, a small hinge-like region, a transmembrane region and a cytoplasmic tail plus 3'-untranslated region. The two clusters of J regions each contain 7 distinct elements, 12 of which may be functional. |
