| First Author | Malissen M | Year | 1986 |
| Journal | Nature | Volume | 319 |
| Issue | 6048 | Pages | 28-33 |
| PubMed ID | 3484541 | Mgi Jnum | J:8144 |
| Mgi Id | MGI:56613 | Doi | 10.1038/319028a0 |
| Citation | Malissen M, et al. (1986) Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements. Nature 319(6048):28-33 |
| abstractText | A germline T-cell receptor variable region (V beta) gene segment (V beta 14) has been mapped 10 kilobases to the 3' side of the constant region (C beta 2) gene. The V beta 14 gene segment is in an inverted transcriptional polarity relative to the diversity-region (D beta) and joining-region (J beta) gene segments and the C beta genes. Analyses of a T-cell clone (J 6.19), which has productively rearranged the V beta 14 gene segment, indicate that the productive V beta-D beta-J beta rearrangement and its reciprocal flank recombination product are linked and located at either border of a chromosomal inversion. These data demonstrate for the first time a linkage between mammalian V and C genes and verify that a functional T-cell receptor V beta gene can be constructed through a chromosomal inversion. |
