| First Author | Lau AL | Year | 1996 |
| Journal | Biochim Biophys Acta | Volume | 1307 |
| Issue | 2 | Pages | 145-8 |
| PubMed ID | 8679697 | Mgi Jnum | J:34404 |
| Mgi Id | MGI:81865 | Doi | 10.1016/0167-4781(96)00061-9 |
| Citation | Lau AL, et al. (1996) Structural analysis of the mouse activin beta C gene. Biochim Biophys Acta 1307(2):145-8 |
| abstractText | Using a mouse activin beta C cDNA probe, we have cloned over 38 kb of genomic DNA encompassing the mouse activin beta C gene. Mouse activin beta C is encoded by 2 exons separated by a large 12.1 kb intron. Exon 1 encodes the 17 amino acid signal peptide and 88 amino acids of the propeptide. Exon 2 encodes the remaining 130 amino acids of the propeptide and the entire 117 amino acid mature peptide. Unlike the activin beta A and beta B expression patterns, Northern blot analysis of adult mouse tissues shows that the activin beta C mRNA is expressed only in the liver as a major species of approximately 2.1 kb. The liver-specific expression of activin beta C suggests an important role of dimeric activin beta C in normal liver function. These studies allow us to address the function of activin beta C in mammalian development. |
