| First Author | Koch U | Year | 2020 |
| Journal | J Exp Med | Volume | 217 |
| Issue | 10 | PubMed ID | 32852523 |
| Mgi Jnum | J:298816 | Mgi Id | MGI:6477553 |
| Doi | 10.1084/jem.20201017 | Citation | Koch U, et al. (2020) A third Notch in colorectal cancer progression and metastasis. J Exp Med 217(10) |
| abstractText | In this issue of JEM, Varga et al. (https://doi.org/10.1084/jem.20191515) describe a mouse model of invasive and metastatic colorectal cancer (CRC) closely resembling the human consensus molecular subtype (CMS) 4 associated with the poorest overall survival of the four CMSs. Transcriptomic and bioinformatic analysis combined with pharmacological and genetic studies identified Notch3 as a promoter of tumor progression and metastasis. NOTCH3 expression was up-regulated in CMS4 CRC patients and associated with tumor staging, lymph node and distant metastasis. These findings feature NOTCH3 as putative therapeutic target for advanced CMS4 CRC patients. |
