| Primary Identifier | MGI:98890 | Organism | mouse, laboratory |
| Chromosome | X | NCBI Gene Number | 22201 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables ubiquitin activating enzyme activity. Acts upstream of or within protein ubiquitination. Predicted to be located in cytosol; mitochondrion; and nucleoplasm. Predicted to be part of heterochromatin. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with bounding membrane of organelle and desmosome. Is expressed in adrenal gland; brain; gonad; liver; and lung. Human ortholog(s) of this gene implicated in VEXAS syndrome and X-linked spinal muscular atrophy 2. Orthologous to human UBA1 (ubiquitin like modifier activating enzyme 1). PHENOTYPE: Male mice hemozygous for a null allele exhibit peri-implantation lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
