| First Author | Jönsson F | Year | 2012 |
| Journal | Blood | Volume | 119 |
| Issue | 11 | Pages | 2533-44 |
| PubMed ID | 22138510 | Mgi Jnum | J:182466 |
| Mgi Id | MGI:5315669 | Doi | 10.1182/blood-2011-07-367334 |
| Citation | Jonsson F, et al. (2012) Human FcgammaRIIA induces anaphylactic and allergic reactions. Blood 119(11):2533-44 |
| abstractText | IgE and IgE receptors (FcepsilonRI) are well-known inducers of allergy. We recently found in mice that active systemic anaphylaxis depends on IgG and IgG receptors (FcgammaRIIIA and FcgammaRIV) expressed by neutrophils, rather than on IgE and FcepsilonRI expressed by mast cells and basophils. In humans, neutrophils, mast cells, basophils, and eosinophils do not express FcgammaRIIIA or FcgammaRIV, but FcgammaRIIA. We therefore investigated the possible role of FcgammaRIIA in allergy by generating novel FcgammaRIIA-transgenic mice, in which various models of allergic reactions induced by IgG could be studied. In mice, FcgammaRIIA was sufficient to trigger active and passive anaphylaxis, and airway inflammation in vivo. Blocking FcgammaRIIA in vivo abolished these reactions. We identified mast cells to be responsible for FcgammaRIIA-dependent passive cutaneous anaphylaxis, and monocytes/macrophages and neutrophils to be responsible for FcgammaRIIA-dependent passive systemic anaphylaxis. Supporting these findings, human mast cells, monocytes and neutrophils produced anaphylactogenic mediators after FcgammaRIIA engagement. IgG and FcgammaRIIA may therefore contribute to allergic and anaphylactic reactions in humans. |
