Primary Identifier | MGI:1934622 | Allele Type | Chemically induced (ENU) |
Gene | Pax6 | Inheritance Mode | Not Specified |
Strain of Origin | BALB/c | Is Recombinase | false |
Is Wild Type | false |
description | The phenotype in the Pax6Leca allelic series (Leca 1-4) produced a range of similar but variable eye phenotypes, with slightly smaller eyes and occasional adhensions between the lens and cornea.
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molecularNote | The mutation underlying the phenotype in Leca1 mice was identified as a T to A substitution at nucleotide position 971 of the Pax6 gene. The mutation occurs in exon 10 and introduces the Val270Glu change in the homeobox domain of the protein. |