| First Author | Toth LA | Year | 1995 |
| Journal | J Neuroimmunol | Volume | 58 |
| Issue | 1 | Pages | 89-99 |
| PubMed ID | 7730450 | Mgi Jnum | J:26576 |
| Mgi Id | MGI:74020 | Doi | 10.1016/0165-5728(94)00193-r |
| Citation | Toth LA, et al. (1995) Strain differences in sleep and other pathophysiological sequelae of influenza virus infection in naive and immunized mice. J Neuroimmunol 58(1):89-99 |
| abstractText | To characterize behavioral and physiological alterations induced by viral respiratory infection, C57BL/6 and BALB/c strains of mice were monitored for 2 days before and 4 days after intranasal inoculation with influenza virus. Both strains developed hypothermia, decrease locomotor activity, and decreased delta-wave amplitude during sleep within 24 h after inoculation. However, infected C57BL/6 mice also spent more time in slow-wave sleep, but infected BALB/c mice did not. The increased SWS in C57BL/6 mice occurred during the lights-off phase of the circadian cycle, and resulted in loss of the normal circadian rhythmicity of sleep. Increased sleep also occurred after viral challenge of immunized C57BL/6 mice, but was not observed after secondary challenge of immunized BALB/c mice. These data indicate that sleep alterations may accompany viral infections in some, but not all, strains of mice. The dissimilar sleep patterns seen in C57BL/6 and BALB/c mice after influenza infection may reflect differences in their immune response to influenza virus. |
