Primary Identifier | MGI:1919599 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 72349 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables protein tyrosine/serine/threonine phosphatase activity. Involved in cellular response to epidermal growth factor stimulus; negative regulation of epidermal growth factor receptor signaling pathway; and regulation of focal adhesion assembly. Predicted to be located in immunological synapse and nucleoplasm. Predicted to be active in cytosol. Is expressed in central nervous system; dorsal root ganglion; retina; and urinary system. Orthologous to human DUSP3 (dual specificity phosphatase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased hemoglobin content and angiogenesis in Matrigel plugs and aortic explants. [provided by MGI curators] |