| First Author | Vanlandewijck M | Year | 2018 |
| Journal | Nature | Volume | 554 |
| Issue | 7693 | Pages | 475-480 |
| PubMed ID | 29443965 | Mgi Jnum | J:261813 |
| Mgi Id | MGI:6154787 | Doi | 10.1038/nature25739 |
| Citation | Vanlandewijck M, et al. (2018) A molecular atlas of cell types and zonation in the brain vasculature. Nature 554(7693):475-480 |
| abstractText | Cerebrovascular disease is the third most common cause of death in developed countries, but our understanding of the cells that compose the cerebral vasculature is limited. Here, using vascular single-cell transcriptomics, we provide molecular definitions for the principal types of blood vascular and vessel-associated cells in the adult mouse brain. We uncover the transcriptional basis of the gradual phenotypic change (zonation) along the arteriovenous axis and reveal unexpected cell type differences: a seamless continuum for endothelial cells versus a punctuated continuum for mural cells. We also provide insight into pericyte organotypicity and define a population of perivascular fibroblast-like cells that are present on all vessel types except capillaries. Our work illustrates the power of single-cell transcriptomics to decode the higher organizational principles of a tissue and may provide the initial chapter in a molecular encyclopaedia of the mammalian vasculature. |
