| Primary Identifier | MGI:1321152 | Organism | mouse, laboratory |
| Chromosome | 2 | NCBI Gene Number | 19281 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Predicted to be involved in several processes, including cellular response to interleukin-6; homophilic cell adhesion via plasma membrane adhesion molecules; and negative regulation of receptor signaling pathway via STAT. Predicted to be located in cell surface and plasma membrane. Predicted to be active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRT (protein tyrosine phosphatase receptor type T). PHENOTYPE: Mice homozygous for a knock-out allele are highly susceptible to carcinogen azoxymethane-induced colon tumors. Mice homozygous for another null allele exhibit depression-like behaviors associated with dysregulated synaptic functions and neurogenesis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
