| Primary Identifier | MGI:5661070 | Allele Type | Endonuclease-mediated |
| Attribute String | No functional change | Gene | Cdh23 |
| Strain of Origin | C57BL/6NTac | Is Recombinase | false |
| Is Wild Type | false | Project Collection | IMPC |
| molecularNote | The CRISPR/Cas9 system was used to correct the Cdh23ahl allele (c.753A>G). This engineered point mutation mimics the C variant of SNP rs257098870 (G on negative gene strand) that is found in the 129S1/SvImJ, C3H/HeSnJ, I/LnJ, YBR/Ei, and MRL/MpJ strains. It restores the G-GT splice donor site that has changed to A-GT in C57BL/6 (and most other strains), where it causes skipping of in-frame exon 7. |
