| First Author | Liu D | Year | 2016 |
| Journal | Arterioscler Thromb Vasc Biol | Volume | 36 |
| Issue | 3 | Pages | 442-5 |
| PubMed ID | 26800562 | Mgi Jnum | J:246305 |
| Mgi Id | MGI:5921808 | Doi | 10.1161/ATVBAHA.115.306861 |
| Citation | Liu D, et al. (2016) Smooth Muscle Hypoxia-Inducible Factor 1alpha Links Intravascular Pressure and Atherosclerosis--Brief Report. Arterioscler Thromb Vasc Biol 36(3):442-5 |
| abstractText | OBJECTIVE: We hypothesized that the hypoxia-inducible factor (HIF) 1alpha in vascular smooth muscle contributes to the development of atherosclerosis, and links intravascular pressure to this process. APPROACH AND RESULTS: Transverse aortic constriction was used to create high-pressure vascular segments in control, apolipoprotein E (ApoE)(-/-), smooth muscle-HIF1alpha(-/-), and ApoE(-/-)xsmooth muscle-HIF1alpha(-/-) double-knockout mice. Transverse aortic constriction selectively induced atherosclerosis in high-pressure vascular segments in young ApoE(-/-) mice on normal chow, including coronary plaques within 1 month. Concomitant deletion of HIF1alpha from smooth muscle significantly reduced vascular inflammation, and attenuated atherosclerosis. CONCLUSIONS: HIF1alpha in vascular smooth muscle plays an important role in the pathogenesis of atherosclerosis, and may provide a mechanistic link between blood pressure, vascular inflammation, and lipid deposition. |
