| First Author | Wen L | Year | 2005 |
| Journal | Immunity | Volume | 23 |
| Issue | 3 | Pages | 297-308 |
| PubMed ID | 16169502 | Mgi Jnum | J:113272 |
| Mgi Id | MGI:3665340 | Doi | 10.1016/j.immuni.2005.08.007 |
| Citation | Wen L, et al. (2005) Evidence of marginal-zone B cell-positive selection in spleen. Immunity 23(3):297-308 |
| abstractText | Antigen receptor-mediated signaling is critical for the development and survival of B cells. However, it has not been established whether B cell development requires a signal from self-ligand engagement at the immature stage, a process known as 'positive selection.' Here, using a monoclonal B cell receptor (BCR) mouse line, specific for the self-Thy-1/CD90 glycoprotein, we demonstrate that BCR crosslinking by low-dose self-antigen promotes survival of immature B cells in culture. In spleen, an increase in BCR signaling strength, induced by low-dose self-antigen, directed naive immature B cells to mature, not into the default follicular B cell fate, but instead into the marginal-zone B cell subset. These data indicate that positive selection can occur in developing B cells and that BCR signal strength is a key factor in deciding between two functionally distinct mature B cell compartments in the microenvironment of the spleen. |
