| First Author | Bonnardel J | Year | 2015 |
| Journal | Cell Rep | Volume | 11 |
| Issue | 5 | Pages | 770-84 |
| PubMed ID | 25921539 | Mgi Jnum | J:228363 |
| Mgi Id | MGI:5706863 | Doi | 10.1016/j.celrep.2015.03.067 |
| Citation | Bonnardel J, et al. (2015) Innate and adaptive immune functions of peyer's patch monocyte-derived cells. Cell Rep 11(5):770-84 |
| abstractText | Peyer's patches (PPs) are primary inductive sites of mucosal immunity. Defining PP mononuclear phagocyte system (MPS) is thus crucial to understand the initiation of mucosal immune response. We provide a comprehensive analysis of the phenotype, distribution, ontogeny, lifespan, function, and transcriptional profile of PP MPS. We show that monocytes give rise to macrophages and to lysozyme-expressing dendritic cells (LysoDCs), which are both involved in particulate antigen uptake, display strong innate antiviral and antibacterial gene signatures, and, upon TLR7 stimulation, secrete IL-6 and TNF, but neither IL-10 nor IFNgamma. However, unlike macrophages, LysoDCs display a rapid renewal rate, strongly express genes of the MHCII presentation pathway, and prime naive helper T cells for IFNgamma production. Our results show that monocytes differentiate locally into LysoDCs and macrophages, which display distinct features from their adjacent villus counterparts. |
