| First Author | Claudio E | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 8 | Pages | 3525-9 |
| PubMed ID | 26371249 | Mgi Jnum | J:280768 |
| Mgi Id | MGI:6369579 | Doi | 10.4049/jimmunol.1500436 |
| Citation | Claudio E, et al. (2015) Cutting Edge: IL-25 Targets Dendritic Cells To Attract IL-9-Producing T Cells in Acute Allergic Lung Inflammation. J Immunol 195(8):3525-9 |
| abstractText | Asthma is a common inflammatory disease of airways that is often associated with type 2 responses triggered by allergens, such as house dust mites (HDMs). IL-25 is a key mucosal cytokine that may be produced by stressed epithelial cells; it rapidly activates type 2 innate lymphoid cells to produce IL-13 and IL-5. When administered directly into lungs, IL-25 induces acute inflammation. However, the mechanisms underlying IL-25-initiated inflammation and the roles of this cytokine in the context of HDM-induced allergic inflammation are not fully understood. We show in this article that lung-resident conventional dendritic cells were direct targets of IL-25. IL-25-stimulated dendritic cells rapidly induced mediators, such as the chemokine CCL17, which, in turn, attracted IL-9-producing T cells. Importantly, these mechanisms also operated during HDM-induced allergic lung inflammation. |
