| First Author | Fang J | Year | 1997 |
| Journal | Biochim Biophys Acta | Volume | 1354 |
| Issue | 3 | Pages | 219-30 |
| PubMed ID | 9427531 | Mgi Jnum | J:44707 |
| Mgi Id | MGI:1101221 | Doi | 10.1016/s0167-4781(97)00104-8 |
| Citation | Fang J, et al. (1997) Mouse latent TGF-beta binding protein-2: molecular cloning and developmental expression. Biochim Biophys Acta 1354(3):219-30 |
| abstractText | The molecular cloning and developmental expression of mouse LTBP-2 are presented here. We established the identity of the cDNA by sequence comparison (80% identity with human LTBP-2) and by chromosome localization (mouse chromosome 12, band D, a region of conserved synteny with the human LTBP-2 gene). In contrast to LTBP-1 and LTBP-3, mouse LTBP-2 apparently is a more modular protein, with proline/glycine-rich sequences always alternating with clusters of cysteine-rich structural motifs. We found for the first time that LTBP-2 gene expression in mouse embryos was restricted to cartilage perichondrium and blood vessels, a somewhat surprising result since other LTBP genes are widely expressed in rodent tissues. Therefore, mouse LTBP-2 may play a critical role in the assembly of latent TGF-beta complexes in developing elastic tissues such as cartilage and blood vessel. |
