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Allele : Pkp4<Gt(pT1Betageo)1Ruiz> plakophilin 4; gene trap 1, Patricia Ruiz

Primary Identifier  MGI:2678397 Allele Type  Gene trapped
Attribute String  Null/knockout, Reporter Gene  Pkp4
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
description  Information submitted to the NCBI Genome Survey Sequences Database (dbGSS) by the German Genetrap Consortium (GGTC) for gene trap cell line W024F10 gives R1 as the ES cell line used to create this allele. The original publication reporting large scale production of gene trap clones using four gene trap vectors says that ES cell-derived chimeras were produced using three ES cell lines (E14.1 (129P2/OlaHsd), R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+), TBV2 (129S2/SvPas)). GGTC records currently say that E14 ES cells were used to generate this allele. Chimeric mice were subsquently bred to C57BL/6 females.
molecularNote  The endogenous locus was disrupted by the insertion of a gene trap vector containing a splice acceptor site followed by Beta-geo and a polyadenylation signal.
  • mutations:
  • Insertion of gene trap vector
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1 Feature

Trail: Allele

Genome

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0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele