| First Author | Tate EL | Year | 1976 |
| Journal | J Gerontol | Volume | 31 |
| Issue | 2 | Pages | 129-34 |
| PubMed ID | 1249400 | Mgi Jnum | J:37917 |
| Mgi Id | MGI:85313 | Doi | 10.1093/geronj/31.2.129 |
| Citation | Tate EL, et al. (1976) A morphometric study of the density of mitochondrial cristae in heart and liver of aging mice. J Gerontol 31(2):129-34 |
| abstractText | Mitochondria in sections of left ventricular wall and liver from C57BL/6J mice, 9, 18, and 36 mo. old, were analyzed using stereological procedures. At 9 mo. of age mu2 cristae surface per mu3 cytoplasm(Sv-c/c was fivefold greater in heart compared with liver reflecting the larger values in the former for both mu2 cristae surface per mu3 mitochondrion (Sv-c/m) and mu3 mitochondria per mu3 cytoplasm (Vv-m):Sv-c/c = Sv-c/m. Vv-m. At 36 mo. in both tissues, Sv-c/c had decreased to 65% of the earlier value. This was due to a decrease in Vv-m alone in heart and both Vv-m and Sv-c/m in liver. In both tissues the number of mitochondria per mu3 cytoplasm (Nv-m) also decreased with age while mu3 organelle average volume (vm) remained constant, supporting previous observations: Vv-m = Nv-m-vm. These data support the views: different tissues in the same organism age independently; and mitochondrial inner and outer membranes have a semi-independent existence. |
