| First Author | Pfaar H | Year | 2002 |
| Journal | Dev Genes Evol | Volume | 212 |
| Issue | 1 | Pages | 43-6 |
| PubMed ID | 11875656 | Mgi Jnum | J:75806 |
| Mgi Id | MGI:2177877 | Doi | 10.1007/s00427-001-0208-x |
| Citation | Pfaar H, et al. (2002) mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Dev Genes Evol 212(1):43-6 |
| abstractText | Here we describe the expression pattern of a previously unknown mouse gene mPet-1.The isolated cDNA codes for an ETS-domain transcription factor of 237 amino acids in length, which is localized to the nucleus. mPet-1 is a member of the winged helix transcription factor gene family like its rat homologue Pet-1 and the human homologue FEV. The start ATG of mPet-1 and the size of the predicted protein are identical to the human FEV. The mPet-1 protein is clearly smaller since it lacks the first 103 N-terminal amino acids of rat Pet-1. mPet- 1 is expressed in central serotonergic (5-hydroxytryptaminergic) neurons located in the mes-/metencephalic raphe nuclei from E11 on until adulthood. In these regions mPet-1 expression co-localizes precisely with the serotonin transporter (Sert),which it initially precedes. Interestingly, mPet-1 was not found in neurons transiently expressing Sert. |
