| First Author | Rial D | Year | 2017 |
| Journal | Neurosci Lett | Volume | 638 |
| Pages | 162-166 | PubMed ID | 28007645 |
| Mgi Jnum | J:241442 | Mgi Id | MGI:5902646 |
| Doi | 10.1016/j.neulet.2016.12.040 | Citation | Rial D, et al. (2017) Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses. Neurosci Lett 638:162-166 |
| abstractText | GPR37 is an orphan G protein-coupled receptor highly expressed in the brain. The precise function of GPR37 is still unknown, but a number of evidences indicate it modulates the dopaminergic system. Here, we aimed to determine the role of GPR37 on the control of cocaine-mediated electrophysiological effects (synaptic transmission and short-term plasticity) in corticostriatal synapses. Accordingly, we evaluated basal synaptic transmission and paired-pulse stimulation (PPS) in wild-type and GPR37KO mice slices. Regardless of the genotype, a low concentration of cocaine (2muM) did not modify basal synaptic transmission. Conversely, a higher dose of cocaine (30muM) decreased synaptic transmission in both genotypes, although with different intensities: approximately 30% in slices from wild-type mice and 45% in slices from GPR37-KO mice. On the other hand, no differences in PPS ratio were observed between wild-type and GPR37-KO cocaine-treated mice. Overall, our data suggest that GPR37 is involved in cocaine-induced modification of basal synaptic transmission without modifying cocaine effects in short-term plasticity. |
