| First Author | Tan JB | Year | 2005 |
| Journal | Nat Immunol | Volume | 6 |
| Issue | 7 | Pages | 671-9 |
| PubMed ID | 15951812 | Mgi Jnum | J:99151 |
| Mgi Id | MGI:3581348 | Doi | 10.1038/ni1217 |
| Citation | Tan JB, et al. (2005) Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nat Immunol 6(7):671-9 |
| abstractText | Signaling through the transmembrane Notch1 receptor directs thymus-seeding progenitors (TSPs) to suppress their B cell potential and 'choose' the T cell fate. Present paradigms suggest that TSPs are contained in the multipotent early T lineage precursor (ETP) subset of thymocytes. However, we show here that the B cell potential of ETPs was not augmented in microenvironments that limited Notch1 activation. Furthermore, low-threshold Notch1 signals suppressed B cell production by TSPs before they reached the ETP stage. Notch1 signals of a higher threshold were needed to drive proliferation of ETPs and development into CD4(+)CD8(+) double-positive thymocytes. Thus, TSPs can be differentiated from all previously identified early T cell progenitors by their robust B cell potential and exquisite sensitivity to Notch1 signals. |
