| Primary Identifier | MGI:2151797 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 116940 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable RNA cap trimethylguanosine synthase activity. Predicted to be involved in 7-methylguanosine cap hypermethylation. Predicted to act upstream of or within methylation. Predicted to be located in cytosol. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human TGS1 (trimethylguanosine synthase 1). PHENOTYPE: Mice homozygous for a null mutation display complete lethality around implantation with embryonic growth arrest, impaired hatching from the zona pellucida, and increased apoptosis. Null MEFs display G2 arrest. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
