| Primary Identifier | MGI:1298230 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 18983 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables poly(A)-specific ribonuclease activity. Involved in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; and regulatory ncRNA-mediated gene silencing. Acts upstream of or within P-body assembly and positive regulation of RNA metabolic process. Located in P-body and nucleus. Part of CCR4-NOT complex. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and skeleton. Orthologous to human CNOT7 (CCR4-NOT transcription complex subunit 7). PHENOTYPE: Homozygous null mice display male sterility with oligo-teratozoospermia, impaired sperm motility, unsynchronized spermatid maturation, and Sertoli cell abnormalities. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
