| First Author | Abu-Lawi KI | Year | 1994 |
| Journal | FEMS Immunol Med Microbiol | Volume | 10 |
| Issue | 1 | Pages | 31-8 |
| PubMed ID | 7874076 | Mgi Jnum | J:22139 |
| Mgi Id | MGI:70024 | Doi | 10.1111/j.1574-695X.1994.tb00008.x |
| Citation | Abu-Lawi KI, et al. (1994) Differing signal requirements for the activation of macrophages from C3H/HeJ and C3H/OuJ mice. FEMS Immunol Med Microbiol 10(1):31-8 |
| abstractText | Endotoxin-associated protein (EP) from Salmonella typhi stimulated the release of prostaglandin E2 (PGE2), interleukin-1 (IL-1), and interferon (IFN) activity in macrophages from the lipopolysaccharide (LPS) responder C3H/OuJ mouse strain. However, only PGE2 and IL-1 were stimulated by EP in macrophages from the LPS nonresponder C3H/HeJ mouse strain. LPS stimulated the release of PGE2, IL-1 and IFN activity in C3H/OuJ macrophages, but not in C3H/HeJ macrophages. The protein kinase C (PKC) activator phorbol myristic acid (PMA) stimulated PGE2 production in both strains but not IL-1 production, suggesting that signalling pathways other than PKC may be involved in IL-1 production. The calcium ionophore ionomycin stimulated PGE2 production in C3H/OuJ but not C3H/HeJ macrophages, suggesting a defective calcium-related pathway in the C3H/HeJ macrophages as compared to the C3H/OuJ cells. |
