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Protein Coding Gene : Tle4 transducin-like enhancer of split 4

Primary Identifier  MGI:104633 Organism  mouse, laboratory
Chromosome  19 NCBI Gene Number  21888
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables DNA-binding transcription factor binding activity; chromatin binding activity; and transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within Wnt signaling pathway and cellular response to leukemia inhibitory factor. Located in nucleus. Is expressed in several structures, including central nervous system; embryo ectoderm; embryo mesenchyme; genitourinary system; and peripheral nervous system ganglion. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor).
PHENOTYPE: Mice homozygous for a knock-out allele are runted and die around 4 weeks of age with leukocytopenia, B cell lymphopenia, reduced bone mineralization and reduced hematopoietic stem cell number and function. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-26070,
  • MGI:2147460,
  • MGI:1930703,
  • expressed sequence tag mouse EST 14,
  • Tle4,
  • expressed sequence tag mouse EST 13,
  • MGI:104835,
  • X83332,
  • Grg4,
  • RIKEN cDNA 5730411M05 gene,
  • MGI:1917740,
  • X83333,
  • transducin-like enhancer of split 4,
  • ESTM14,
  • EST X83332,
  • MGD-MRK-28130,
  • AA792082,
  • 5730411M05Rik,
  • MGD-MRK-28129,
  • MGI:104836,
  • ESTM13,
  • Bce1,
  • expressed sequence AA792082,
  • EST X83333

Features --> Cross References

Genome

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

7 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

1 Driver For