| Primary Identifier | MGI:1927165 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 56335 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables mRNA (N6-adenosine)-methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and mRNA destabilization. Part of RNA N6-methyladenosine methyltransferase complex. Is active in nucleus. Is expressed in brain; genitourinary system; hindlimb; intestine; and liver. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E8.5 with a deficiency in adopting the epiblast egg cylinder. Conditional homozygous knockout in the ovary or in primordial germ cells in testes causes sterility. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
