| First Author | Driessen C | Year | 2003 |
| Journal | Vision Res | Volume | 43 |
| Issue | 28 | Pages | 3075-9 |
| PubMed ID | 14611944 | Mgi Jnum | J:92315 |
| Mgi Id | MGI:3052382 | Doi | 10.1016/s0042-6989(03)00483-8 |
| Citation | Driessen C, et al. (2003) Novel targeting strategy for generating mouse models with defects in the retinoid cycle. Vision Res 43(28):3075-9 |
| abstractText | In addition to RDH5, other enzymes capable of oxidizing 11-cis-retinol are present within the retinal pigment epithelium, Muller cells and/or photoreceptors. Candidate proteins have meanwhile been identified. To study the physiological and pathological aspects of these enzymes, mice in which these genes are no longer functional are being generated. A fast-targeting strategy for the disruption of genes was developed. Generation of double and triple knockouts will aid in determining if these retinol dehydrogenases are responsible for the remaining 11-cis-retinol oxidation observed in RDH5 knockout animals. |
