First Author | Cornell B | Year | 2016 |
Journal | BMC Res Notes | Volume | 9 |
Pages | 180 | PubMed ID | 27001213 |
Mgi Jnum | J:242528 | Mgi Id | MGI:5905530 |
Doi | 10.1186/s13104-016-1980-z | Citation | Cornell B, et al. (2016) Deficiency of 14-3-3epsilon and 14-3-3zeta by the Wnt1 promoter-driven Cre recombinase results in pigmentation defects. BMC Res Notes 9:180 |
abstractText | BACKGROUND: The seven 14-3-3 protein isoforms bind to numerous proteins and are involved in a wide variety of cellular events, including the cell cycle, cell division, apoptosis and cancer. We previously found the importance of 14-3-3 proteins in neuronal migration of pyramidal neurons in the developing cortex. Here, we test the function of 14-3-3 proteins in the development of neural crest cells in vivo using mouse genetic approaches. RESULTS: We found that 14-3-3 proteins are important for the development of neural crest cells, in particular for the pigmentation of the fur on the ventral region of mice. CONCLUSIONS: Our data obtained from the 14-3-3epsilon/14-3-3zeta/Wnt1-Cre mice strongly indicate the importance of 14-3-3 proteins in the development of melanocyte lineages. |