| First Author | Duijf PH | Year | 2013 |
| Journal | Oncogene | Volume | 32 |
| Issue | 40 | Pages | 4727-36 |
| PubMed ID | 23318433 | Mgi Jnum | J:203231 |
| Mgi Id | MGI:5525213 | Doi | 10.1038/onc.2012.616 |
| Citation | Duijf PH, et al. (2013) The cancer biology of whole-chromosome instability. Oncogene 32(40):4727-36 |
| abstractText | One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic framework to explain this paradox. We also review the tumor-promoting and tumor-suppressing consequences of W-CIN. Importantly, we do this in the context of cancer as a complex systemic disease, rather than as a simple linearly progressing disorder that arises from a single abnormal cell population. Accordingly, we highlight the often neglected effects of W-CIN on key non-cell-autonomous entities, such as the immune system and the tumor microenvironment. Distinct tissue-specific susceptibilities to W-CIN-induced tumorigenesis and the clinical implications of W-CIN are also discussed. |
