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Protein Coding Gene : Upf3a UPF3 regulator of nonsense transcripts homolog A (yeast)
Primary Identifier  MGI:1914281 Organism  mouse, laboratory
Chromosome  8 NCBI Gene Number  67031
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable mRNA binding activity; protein sequestering activity; and telomeric DNA binding activity. Involved in negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Acts upstream of or within positive regulation of mRNA cis splicing, via spliceosome. Located in neuron projection. Is expressed in central nervous system. Orthologous to human UPF3A (UPF3A regulator of nonsense mediated mRNA decay).
PHENOTYPE: The gene product protects against mRNA transcript degradation. Homozygous constitutive KO is embryonic lethal. Homozygous conditional KO in testes leads to reduced male fertility. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA 4930546M19 gene,
  • UPF3,
  • 4930546M19Rik,
  • 2600001C03Rik,
  • MGI:1922480,
  • RIKEN cDNA 2600001C03 gene,
  • Upf3a,
  • UPF3 regulator of nonsense transcripts homolog A (yeast),
  • RENT3A
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