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Protein Coding Gene : Psmb9 proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)
Primary Identifier  MGI:1346526 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  16912
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0)

Predicted to enable endopeptidase activity and proteasome binding activity. Acts upstream of or within antigen processing and presentation and response to bacterium. Part of proteasome core complex and spermatoproteasome complex. Is expressed in thymus primordium. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to human PSMB9 (proteasome 20S subunit beta 9).
PHENOTYPE: Mice homozygous for disruptions in this gene have a grossly normal phenotype but suffer from increased susceptibility to some viruses and have an increased risk of tumor development. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-11821,
  • Lmp-2,
  • Psmb9,
  • large multifunctional protease 2,
  • low molecular weight polypeptide 2,
  • proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2),
  • Lmp2,
  • MGI:96797,
  • MGD-MRK-11823
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