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Protein Coding Gene : Atp6v0c ATPase, H+ transporting, lysosomal V0 subunit C
Primary Identifier  MGI:88116 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  11984
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Predicted to enable P-type proton-exporting transporter activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of autophagic cell death; positive regulation of ERK1 and ERK2 cascade; and positive regulation of Wnt signaling pathway. Predicted to act upstream of or within proton transmembrane transport. Part of proton-transporting V-type ATPase complex and transmembrane transporter complex. Is expressed in several structures, including alimentary system; blastocyst; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Orthologous to human ATP6V0C (ATPase H+ transporting V0 subunit c).
PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality. [provided by MGI curators]
  • synonyms:
  • Atp6c2,
  • ATPase, H+ transporting, lysosomal V0 subunit C,
  • MGD-MRK-1476,
  • ATPase-like vacuolar proton channel, related sequence 1,
  • MGI:107616,
  • MGD-MRK-36468,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16 kDa,
  • proteolipid,
  • Atp6v0c,
  • Atpl,
  • Atpl-rs1,
  • ATPase-like vacuolar proton channel,
  • H(+)-ATPase (mvp),
  • Atp6l,
  • ATPase, H+ transporting, lysosomal (vacuolar proton pump) 16kD,
  • ATPase, H+ transporting, lysosomal 2,
  • MGD-MRK-36190,
  • PL16
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