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Protein Coding Gene : Akt3 thymoma viral proto-oncogene 3

Primary Identifier  MGI:1345147 Organism  mouse, laboratory
Chromosome  1 NCBI Gene Number  23797
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Predicted to enable ATP binding activity; protein kinase C binding activity; and protein serine/threonine kinase activity. Involved in positive regulation of angiogenesis and positive regulation of artery morphogenesis. Acts upstream of or within several processes, including brain morphogenesis; positive regulation of TOR signaling; and positive regulation of cell size. Predicted to be located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; integumental system; nervous system; and retina. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).
PHENOTYPE: Homozygous null mice exhibit a 20% decrease in brain size and have smaller and fewer cells in the brain. Mice heterozygous for an ENU-induced mutation exhibit increased seizures (sporadic and induced) and increased brain weight and size. [provided by MGI curators]
  • synonyms:
  • thymoma viral proto-oncogene 3,
  • Akt3,
  • MGI:3628555,
  • MGI:2138357,
  • RIKEN cDNA D930002M15 gene,
  • D930002M15Rik,
  • expressed sequence AI851531,
  • Nmf350,
  • neuroscience mutagenesis facility, 350,
  • AI851531,
  • PKB gamma

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0 CDSs

0 Exons

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3 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

64 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

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Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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