| First Author | Kleiter N | Year | 2002 |
| Journal | Cytogenet Genome Res | Volume | 97 |
| Issue | 1-2 | Pages | 100-5 |
| PubMed ID | 12438746 | Mgi Jnum | J:79790 |
| Mgi Id | MGI:2388939 | Doi | 10.1159/000064062 |
| Citation | Kleiter N, et al. (2002) Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11. Cytogenet Genome Res 97(1-2):100-5 |
| abstractText | We have characterized a 185-kb contig surrounding a transgene on distal mouse chromosome 11, the insertion of which has caused a recessive phenotype with skeletal malformations. By cDNA selection and sequencing we have found six genes (Lasp1, Rpl23, Mllt6, Pip5k2b, Psmb3, Zfp144), one truncated gene (Mel13), and one pseudogene (Rps15-ps) within this region. The murine Mllt6 gene is new, it was identified by its high homology (90% identity) with the human homologue MLLT6. Psmb3 and Pip5k2b had not yet been assigned to mouse chromosomes. A comparison with the corresponding region on human chromosome 17q12 revealed several small-scale rearrangements during evolutionary divergence within this cluster of densely packed genes. |
