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Publication : Changes in LDH isozyme pattern in uterine fluid of mice during early pregnancy.

First Author  Rathour NP Year  1997
Journal  Horm Metab Res Volume  29
Issue  9 Pages  462-4
PubMed ID  9370117 Mgi Jnum  J:44353
Mgi Id  MGI:1099931 Doi  10.1055/s-2007-979078
Citation  Rathour NP, et al. (1997) Changes in LDH isozyme pattern in uterine fluid of mice during early pregnancy. Horm Metab Res 29(9):462-4
abstractText  The total LDH activity in the uterine fluid of mice shows a rising trend from the first day after mating (DAM-1) to the seventh day after mating (DAM-7). This suggests that LDH activity increases as gestation progresses. During early pregnancy, M-isozymes of LDH show a predominance from DAM-1 to DAM-3 in the uterine luminal fluid of mice, while H-isozyme shows a rising level from DAM-5 (implantation day) and attains a maximum level at DAM-7 (the post-implantation period). Such shift of M-isozymes into H-isozymes of LDH (lactate dehydrogenase) during pre-implantation (DAM-3) to post-implantation (DAM-7) period changes the uterine luminal environment from anaerobic to aerobic condition which is more conducive for the normal development, implantation and survival of the growing blastocyst.
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