| First Author | Poussier P | Year | 1999 |
| Journal | Semin Immunol | Volume | 11 |
| Issue | 4 | Pages | 293-303 |
| PubMed ID | 10441215 | Mgi Jnum | J:56838 |
| Mgi Id | MGI:1342792 | Doi | 10.1006/smim.1999.0185 |
| Citation | Poussier P, et al. (1999) Speculation on the lineage relationships among CD4(-)8(+) gut-derived T cells and their role(s). Semin Immunol 11(4):293-303 |
| abstractText | The thymus-independent T lymphopoietic capacity of the murine intestinal mucosa has been established. Cryptopatches have now been identified as the location of the elusive precursors for gut-derived T cells. These cryptopatch cells have been shown to give rise to intestinal T cells expressing either TCRgammadelta or TCRalphabeta. Here we discuss the role of MHC in the development and selection of gut-derived T cells. Through the analysis of iIEL selection in animals expressing a transgenic TCRalphabeta, in the presence or absence of p56(lck), we discuss lineage relationships among CD4(-)8(+) iIEL subsets, and their possible function(s). Copyright 1999 Academic Press. |
