| Primary Identifier | MGI:3663636 | Allele Type | Transgenic |
| Attribute String | Hypomorph, Inserted expressed sequence | Gene | Ssbp3 |
| Strain of Origin | (C57BL/6 x C3H/He)F2 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene construct was an 11 kb genomic fragment containing all exons of the human SOD1 gene and modified to have a 2 bp deletion associated with human amyotrophic lateral sclerosis. Four copies of the transgene were found to be inserted into intron 4 of the Ssbp3 gene, accompanying a 9 bp deletion. This produced a hypomorphic allele with ~32% of the expression level seen in wild-type embryos. |
