| First Author | Bauer MF | Year | 1999 |
| Journal | FEBS Lett | Volume | 464 |
| Issue | 1-2 | Pages | 41-7 |
| PubMed ID | 10611480 | Mgi Jnum | J:59270 |
| Mgi Id | MGI:1351264 | Doi | 10.1016/s0014-5793(99)01665-8 |
| Citation | Bauer MF, et al. (1999) The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett 464(1-2):41-7 |
| abstractText | The Mohr-Tranebjaerg syndrome (MTS), a neurodegenerative syndrome characterized by progressive sensorineural hearing loss, dystonia, mental retardation and blindness, is a mitochondrial disease caused by mutations in the deafness/dystonia peptide 1 (DDP1) gene. DDP1 shows similarity to the yeast proteins Tim9, Tim10 and Tim12, components of the mitochondrial import machinery for carrier proteins. Here, we show that DDP1 belongs to a large family of evolutionarily conserved proteins. We report the identification, chromosomal localization and expressional analysis of six human family members which represent further candidate genes for neurodegenerative diseases. |
