| First Author | Macleod K | Year | 1999 |
| Journal | Curr Opin Genet Dev | Volume | 9 |
| Issue | 1 | Pages | 31-9 |
| PubMed ID | 10072353 | Mgi Jnum | J:53158 |
| Mgi Id | MGI:1331343 | Doi | 10.1016/s0959-437x(99)80005-7 |
| Citation | Macleod K (1999) pRb and E2f-1 in mouse development and tumorigenesis. Curr Opin Genet Dev 9(1):31-9 |
| abstractText | Our understanding of how RB and E2F-1 function has progressed significantly from the model in which RB negatively regulates expression of genes required for S phase by binding to and inhibiting E2F-1. Both RB and E2F-1 have been shown recently to possess additional properties and mechanisms of regulation relevant to developmental and tumorigenic processes. In particular, it is now realised that RB has E2F-independent tumor suppressor functions which rely upon the ability of RB to induce differentiation. For its part, E2F-1 is unique amongst E2F family members in its capacity to induce apoptosis and this function is clearly relevant to our appreciation of E2F-1 as a conditional tumor suppressor. E2F-1 can induce both apoptosis and S-phase transition and whether E2F-1 acts as an oncogene or a tumor-suppressor gene may depend on the extent to which E2F-1 induces apoptosis as opposed to G1/S transition. |
