| First Author | Weskamp G | Year | 1994 |
| Journal | Proc Natl Acad Sci U S A | Volume | 91 |
| Issue | 7 | Pages | 2748-51 |
| PubMed ID | 8146185 | Mgi Jnum | J:30468 |
| Mgi Id | MGI:77978 | Doi | 10.1073/pnas.91.7.2748 |
| Citation | Weskamp G, et al. (1994) A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A 91(7):2748-51 |
| abstractText | Disintegrins are short soluble integrin ligands that were initially identified in snake venom. A previously recognized cellular protein with a disintegrin domain was the guinea pig sperm protein PH-30, a protein implicated in sperm-egg membrane binding and fusion. Here we present peptide sequences that are characteristic for several cellular disintegrin-domain proteins. These peptide sequences were deduced from cDNA sequence tags that were generated by polymerase chain reaction from various mouse tissue and a mouse muscle cell line. Northern blot analysis with four sequence tags revealed distinct mRNA expression patterns. Evidently, cellular proteins containing a disintegrin domain define a superfamily of potential integrin ligands that are likely to function in important cell-cell and cell-matrix interactions. |
