| First Author | van Beelen AJ | Year | 2007 |
| Journal | Immunity | Volume | 27 |
| Issue | 4 | Pages | 660-9 |
| PubMed ID | 17919942 | Mgi Jnum | J:126102 |
| Mgi Id | MGI:3760552 | Doi | 10.1016/j.immuni.2007.08.013 |
| Citation | van Beelen AJ, et al. (2007) Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27(4):660-9 |
| abstractText | How the development of antibacterial T helper 17 (Th17) cells is selectively promoted by antigen-presenting dendritic cells (DCs) is unclear. We showed that bacteria, but not viruses, primed human DCs to promote IL-17 production in memory Th cells through the nucleotide oligomerization domain 2 (NOD2)-ligand muramyldipeptide (MDP), a derivative of bacterial peptidoglycan. MDP enhanced obligate bacterial Toll-like receptor (TLR) agonist induction of IL-23 and IL-1, which promoted IL-17 expression in T cells. The role of NOD2 in this IL-23-IL-1-IL-17 axis could be confirmed in NOD2-deficient DCs, such as DCs from selected Crohn's disease patients. Thus, antibacterial Th17-mediated immunity in humans is orchestrated by DCs upon sensing bacterial NOD2-ligand MDP. |
