| Type | MGI:General | Description | injection of ISO (10 mg/kg) followed by a 20 min period of exercise on the treadmill significantly reduces the latency of heterozygotes to fall from the accelerating rotarod by ~15 sec, whereas wild-type mice remain unaffected a higher dose of ISO (20 mg/kg) followed exercise reduces the latency of heterozygotes to fall to a similar degree, whereas wild-type mice are only moderately affected injection of ISO (10 mg/kg) followed by exercise significantly increases the number of hindfoot missteps on the balance beam in heterozygotes, but has little effect on wild-type littermates injection of acetazolamide (AZT), a carbonic anhydrase inhibitor, at 10 min prior to ISO injection (20 mg/kg) followed by exercise abolishes the reduction in latency to fall from the accelerating rotarod in heterozygous mice similalry, ATZ significantly decreases the number of hindfoot missteps on the balance beam, induced by ISO and exercise in heterozygous mice |
