| First Author | Curtsinger JM | Year | 2012 |
| Journal | J Immunol | Volume | 189 |
| Issue | 2 | Pages | 659-68 |
| PubMed ID | 22706089 | Mgi Jnum | J:189538 |
| Mgi Id | MGI:5446087 | Doi | 10.4049/jimmunol.1102727 |
| Citation | Curtsinger JM, et al. (2012) Autocrine IFN-gamma promotes naive CD8 T cell differentiation and synergizes with IFN-alpha to stimulate strong function. J Immunol 189(2):659-68 |
| abstractText | Autocrine IFN-gamma signaling is important for CD4 differentiation to Th1 effector cells, but it has been unclear whether it contributes to CD8 T cell differentiation. We show in this paper that naive murine CD8 T cells rapidly and transiently produce low levels of IFN-gamma upon stimulation with Ag and B7-1, with production peaking at approximately 8 h and declining by 24 h. The autocrine IFN-gamma signals for upregulation of expression of T-bet and granzyme B and induces weak cytolytic activity and effector IFN-gamma production. IFN-alpha acts synergistically with IFN-gamma to support development of strong effector functions, whereas IL-12 induces high T-bet expression and strong function in the absence of IFN-gamma signaling. Thus, IFN-gamma is not only an important CD8 T cell effector cytokine, it is an autocrine/paracrine factor whose contributions to differentiation vary depending on whether the response is supported by IL-12 or type I IFN. |
