| First Author | Johnson JR | Year | 1995 |
| Journal | Radiat Res | Volume | 144 |
| Issue | 1 | Pages | 82-9 |
| PubMed ID | 7568775 | Mgi Jnum | J:29049 |
| Mgi Id | MGI:76573 | Citation | Johnson JR, et al. (1995) Relative biological effectiveness of tritium for induction of myeloid leukemia in CBA/H mice. Radiat Res 144(1):82-9 |
| abstractText | To help resolve uncertainties as to the most appropriate weighting factor for tritium beta rays, a large experiment was carried out to measure the relative biological effectiveness (RBE) of tritiated water compared to X rays for the induction of myeloid leukemia in male mice of the CBA/H strain. The study was designed to estimate the lifetime incidence of myeloid leukemia in seven groups of about 750 mice each; radiation exposures were approximately 0, 1, 2 and 3 Gy both for tritiated water and for X rays. The lifetime incidence of leukemia in these mice increased from 0.13% in the control group to 6-8% in groups exposed to higher radiation doses. The results were fitted to various equations relating leukemia incidence to radiation dose, using both the raw data and data corrected for cumulative mouse-days at risk. The calculated RBE values for tritium beta rays compared to X rays ranged from 1.0 +/- 0.5 to 1.3 +/- 0.3. A best estimate of the RBE for this experiment was about 1.2 +/- 0.3. A wR value of 1 would thus appear to be more appropriate than a wR of 2 for tritium beta rays. |
