Primary Identifier | MGI:2135607 | Organism | mouse, laboratory |
Chromosome | 10 | NCBI Gene Number | 93759 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0) Enables several functions, including p53 binding activity; protein lysine deacetylase activity; and transcription coregulator activity. Involved in several processes, including regulation of fat cell differentiation; regulation of gene expression; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and negative regulation of macromolecule biosynthetic process. Located in mitochondrion and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; gonad; heart; metanephros; and sensory organ. Used to study Alzheimer's disease; nephrogenic diabetes insipidus; and steatotic liver disease. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). PHENOTYPE: Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies. [provided by MGI curators] |