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Protein Coding Gene : Sirt1 sirtuin 1

Primary Identifier  MGI:2135607 Organism  mouse, laboratory
Chromosome  10 NCBI Gene Number  93759
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables several functions, including p53 binding activity; protein lysine deacetylase activity; and transcription coregulator activity. Involved in several processes, including regulation of fat cell differentiation; regulation of gene expression; and regulation of intracellular signal transduction. Acts upstream of or within several processes, including behavioral response to starvation; cellular response to leukemia inhibitory factor; and negative regulation of macromolecule biosynthetic process. Located in mitochondrion and nucleus. Part of heterochromatin. Is expressed in several structures, including brain; gonad; heart; metanephros; and sensory organ. Used to study Alzheimer's disease; nephrogenic diabetes insipidus; and steatotic liver disease. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1).
PHENOTYPE: Mice homozygous for a knock-out allele show embryonic and fetal lethality, abnormal embryogenesis, and abnormal cellular phenotypes of derived MEFs. Mice homozygous for other knock-out alleles may exhibit peri- and postnatal lethality and heart, mammary gland, eye, and reproductive system anomalies. [provided by MGI curators]
  • synonyms:
  • Sirt1,
  • AA673258,
  • Sir2alpha,
  • Sir2,
  • MGI:2143506,
  • sirtuin 1,
  • expressed sequence AA673258

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

3 Involved In Mutations

0 Strain

0 Transcripts

7 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

12 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For