| First Author | Reed-Geaghan EG | Year | 2020 |
| Journal | J Exp Med | Volume | 217 |
| Issue | 4 | PubMed ID | 31967645 |
| Mgi Jnum | J:289881 | Mgi Id | MGI:6432557 |
| Doi | 10.1084/jem.20191374 | Citation | Reed-Geaghan EG, et al. (2020) Plaque-associated myeloid cells derive from resident microglia in an Alzheimer's disease model. J Exp Med 217(4) |
| abstractText | Alzheimer's disease (AD) is accompanied by a robust inflammatory response mediated by plaque-associated myeloid cells of the brain. These cells exhibit altered gene expression profiles and serve as a barrier, preventing neuritic dystrophy. The origin of these cells has been controversial and is of therapeutic importance. Here, we genetically labeled different myeloid populations and unequivocally demonstrated that plaque-associated myeloid cells in the AD brain are derived exclusively from resident microglia, with no contribution from circulating peripheral monocytes. |
